School of Medicine

Wayne State University School of Medicine

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Ladislau Kovari

Our laboratory performs structure-function studies of viral drug targets using structural, biochemical and computational methods. We use X-ray crystallography and molecular modeling to explore HIV drug resistance, perform structure-based drug design against viruses (HIV-1 and hepatitis C virus) and investigate the problem of molecular recognition and protein flexibility. The objective of our research is to understand and overcome the mechanisms of viral resistance in particular as it relates to HIV and HCV. To do this, we determine the crystal structures of multidrug-resistant HIV-1 protease clinical isolates in order to elucidate the mechanisms of HIV drug resistance and help design the next generation of HIV-1 protease inhibitors.

Kovari Group web page

University of Tennessee, Ph.D., 1992

Purdue University, 1992-1997, Structural Biology (X-ray Crystallography)


Research Areas:

  • Structure of HIV and hepatitis C virus proteins by x-ray crystallography
  • Mechanisms of viral drug resistance
  • Human myelin protein zero

Kovari Group research