School of Medicine

Wayne State University School of Medicine

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Domenico L. Gatti, M.D., Ph.D
Associate Professor

My laboratory is involved in the development of new computational tools to study enzyme mechanisms and metabolic pathways, and to identify coevolving elements inside protein structures.

View Laboratory Website.

Ph.D., University of Bari, Italy, 1987

M.D., Catholic University of Rome, Italy, 1982


The study of enzymes and other biological macromolecules by a combination of tools including genetic engineering, steady- and pre-steady-state kinetics, circular dichroism, light scattering, X-ray crystallography and molecular modeling.

Research Areas:
Structure of proteins involved in energy transduction in bacterial and eukaryotic membranes



Ackerman SH, Gatti DL. “Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the hydrolysis reaction.” PLoS One. 8, Issue 1 | e55136, 2013.

Ackerman SH, Tillier ER, Gatti DL. “Accurate simulation and detection of coevolution signals in multiple sequence alignments.” PLoS One. 7, Issue 10 | e47108, 2012.

Gatti DL. “Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the post-hydrolysis reactions.” PLoS One. 7, Issue 1 | e30079, 1-17, 2012.

Acin-Perez R., Gatti D.L., Bai Y, Manfredi G. “Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation.” Cell Metab. 13, 712-9, 2011.

Ackerman S.H, and Gatti D.L. “The contribution of co-evolving residues to the stability of KDO8P synthase”, PLoS ONE, 6, Issue 3 | e17459, 1-14, 2011.

Tao P, Schlegel HB, Gatti D.L. “Common basis for the mechanism of metallo and non-metallo KDO8P synthases.” J Inorg Biochem. 104, 1267-75, 2010.

Meulemans A, Seneca S, Pribyl T, Smet J, Alderweirld V, Waeytens A, Lissens W, Van Coster R, De Meirleir L, di Rago JP, Gatti D.L., Ackerman SH. “Defining the pathogenesis of the human ATP12p W94R mutation using a saccharomyces cerevisiae yeast model.” J Biol Chem. 285, 4099-109, 2010.

Tao P, Gatti D.L., Schlegel HB. “The energy landscape of 3-deoxy-D-manno-octulosonate 8-phosphate synthase.” Biochemistry. 48, 11706-14, 2009.

Ludlam A, Brunzelle J, Pribyl T, Xu X, Gatti D.L, Ackerman SH. “Chaperones of F1-ATPase.” J Biol Chem. 284, 17138-46, 2009.

Kona F, Tao P, Martin P, Xu X, Gatti D.L. “Electronic structure of the metal center in the Cd(2+), Zn(2+), and Cu(2+) substituted forms of KDO8P synthase: implications for catalysis.” Biochemistry. 48, 3610-30, 2009.

Kona, F., Xu, X., Martin, P., Kuzmic, P., and Gatti, D.L. “Structural and mechanistic changes along an engineered path from metallo to nonmetallo 3-deoxy-D-manno octulosonate 8-phosphate synthases.” Biochemistry 46, 4532-44, 2007. (This article had a special commentary in Science).