School of Medicine

Wayne State University School of Medicine
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About the Department

Biochemistry and Molecular Biology have become central to the biological revolution that is transforming the life of all humans. Our goal is to prepare students for active participation in this exciting area of human endeavor, by investigating the molecular mechanisms underlying biological processes, with emphasis by focusing on the relationship between macromolecular structure and function. Our research programs range from investigations of the detailed interactions of biological molecules and to broad studies of evolutionary processes. The department has undergone a major expansion in the area of in structural biology, with new faculty who have nationally ranked programs in x-ray crystallography and nuclear magnetic resonance. Read more.

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Calendar of Events

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Cardiology VHD Lecture Series - MR Part 3
December 9 2016 at 12:00 PM
DMC Heart Hospital
Featuring Dr. Luis Afonso. Presented by the WSU Department of Internal Medicine.
Internal Medicine Faculty Luncheon Meeting
December 9 2016 at 12:00 PM
University Health Center
Presented by the WSU Department of Internal Medicine.
Department of Pharmacology Seminar - Bone Marrow Adipocytes Alter the Metabolic Phenotype of Metastic Prostate Cancer Cells through the Activation of HIF-1a
December 9 2016 at 1:00 PM
Scott Hall
This Michael E. Buck, M.D., Seminar in Pharmacology features John Dietrich, a graduate student in the Cancer Biology Program. Presented by the WSU Department of Pharmacology.
IBio Seminar With Dr. David Fresco, - Seeing Clearly in the Mind's Eye: An Affect Science Approach to Depression and Health Behavior Change
December 12 2016 at 11:00 AM
Integrative Biosciences Center
NOTE: THIS EVENT HAS BEEN MOVED TO DEC. 13! The Wayne State University community is invited to attend an IBio Seminar with guest speaker, David Fresco, Ph.D., professor in the Department of Psychology at Kent State University, Tuesday, December 13, 2016 at 11:00 a.m. in the first floor seminar room of IBio, located at 6135 Woodward. The seminar is free; registration is requested. Dr. Fresco wil be presenting "Seeing Clearly in the Mind's Eye: An Affect Science Approach to Depression and Health Behavior Change." Dr. Fresco is professor of psychology at Kent State University and adjunct associate professor of psychiatry at Case Western Reserve University School of Medicine. He directs the Psychopathology and Emotion Regulation Laboratory (PERL) and is a co-director of the Kent Electrophysiological Neuroscience Laboratory (KENL). He received his Ph.D. from the University of North Carolina at Chapel Hill and completed a postdoctoral fellowship at Temple University. His program of research adopts an affective science perspective to the study of anxiety and mood disorders. Working at the interface of cognitive behavioral and emotion regulation approaches, he conducts survey, experimental, and treatment research to examine factors associated with major depressive disorder (MDD) and generalized anxiety disorder (GAD) including metacognitive factors (e.g., explanatory flexibility, decentering, rumination, worry), peripheral psychophysiology, and emerging work from affective neuroscience, utilizing neuroimaging and electrophysiological techniques. Another focus of the PERL lab is the development of treatments informed by affective and contemplative neuroscience findings that incorporate mindfulness meditation and other practices derived from Buddhist mental training exercises. Much of his NIH-funded treatment research has focused on the infusion of mindfulness into Western psychosocial treatments. Presently, he is PI and Co-PI on two NIH-funded grants examining neurobehavioral mechanisms and efficacy of mindfulness-enriched treatments. He is also associate editor for two journals - the Journal of Consulting and Clinical Psychology, and Cognitive Therapy and Research. He is also a frequent reviewer for the Interventions Committee of Adult Disorders (ITVA) of the National Institute of Mental Health and various study sections of the National Center for Complementary and Integrative Health (NCCIH). ABSTRACT Self-reflection, also referred to as self-referentiality, is perhaps the most defining characteristic of being human and may represent the default state of the brain. This ability to hold one’s self in awareness offers many advantages for survival and pursuit of reward as well as socially and empathically relating to others.  Self-referentiality is typically associated with neural activation in the default mode network located primarily along the cortical midline of the brain. Although clearly associated with physical and mental well-being, these same neural regions and the corresponding neurobehavioral phenomena are also implicated in many forms of psychiatric and physical illness.  A major focus of Dr. Fresco’s program of research, and his NIH funding, has been in better understanding the nature, measurement, and treatment implications of self-referentiality in relation to emotional disorders and physical illnesses. In the course of his presentation, Dr. Fresco will illustrate how negative self-referentiality (e.g., rumination, worry, self-criticism) undermines emotional and physical well-being and how decentering, defined as a metacognitive capacity to observe items that arise in the mind (e.g., thoughts, feelings, memories) with healthy psychological distance, greater self-awareness and perspective-taking is associated with overcoming emotional disorders and managing chronic health conditions.  In doing so, he will focus on current and future research directions elucidating the neurobehavioral markers of negative self-referentiality and decentering and how interventions that promote decentering may engender larger and more durable treatment responses. We hope you can join us for this interesting IBio seminar!
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