School of Medicine

Wayne State University School of Medicine

1991-2000 Graduates


Ann Bouvier, Ph.D.
Thesis Title: Subdomain organization and function in the carbamoyl phosphate synthetase of E. coli and mammalian CAD
Advisor:  David Evans

Ruben Gomez, Ph.D.
Thesis Title: Examination of the effects of two mutations in the ampC structural gene of enterobacter cloacae P99
Advisor:  Steve Lerner

Andrew Grzanowski, Ph.D.
Thesis Title: Phenylbutyrate targets in yeast
Advisor:  William Brusilow

Anura Hewagama, Ph.D.
Thesis Title: Mechanism of glutamine hydrolysis and interdomain communication by mammalian carbamoyl phosphate
Advisor:  David Evans

Isabelle Lehoux, Ph.D.
Thesis Title: Mechanistic studies of (S)-mandelate dehydrogenase from Pseudomonas putida, a flavin-dependent alpha-hydroxy acid dehydrogenase
Advisor:  Bharati Mitra

Yan Sun, Ph.D.
Thesis Title:
Advisor:  Barry Rosen

Jian Yang, Ph.D.
Thesis Title: Structure of connective tissue activating peptide-III complex with polyvinylsulfonic acid and structure comparison of two platelet factor 4 mutants with the wild-type
Advisor:  Brain Edwards



Askar Kuchumov, Ph.D.
Thesis Title: The role of linker subunits in the reassembly of hexagonal bilayer structure of Lumbricus hemoglobin
Advisor:  Serge Vinogradov

Jiaxin Li, Ph.D.
Thesis Title: Structural and functional characterization of the ARSA ATPASE, the catalytic subunit of the arsenic resistance pump
Advisor:  Barry Rosen

Jiyang Liu, Ph.D.
Thesis Title: Structure/function relationship study in ARSC arsenate reductase of Escherichia Coli plasmid R773
Advisor:  Barry Rosen

Nisha Sahay, Ph.D.
Thesis Title: Characterization of the regulatory domain of the mammalian multifunctional De Novo pyrimidne biosynthetic enzyme CAD
Advisor:  David Evans

Chun Xu, Ph.D.
Thesis Title: Dimerization is essential for DNA binding and repression by the ARSR metalloregulatory protein of ESCHERICHIA COLI
Advisor:  Barry Rosen



Jianfan Wang, Ph.D.
Thesis Title: Glucose repression of MAL6 gene expression in Saccharomyces cerevisiae
Advisor:  Richard Needleman


Yanxiang Chen, Ph.D.
Thesis Title: Mechanisms of arsenical resistance in Escherichia Coli: the roles of ARSD and ARSB in metalloregulation and
transport of arsenite
Advisor:  Barry Rosen

Diane Deutsch, Ph.D.
Thesis Title: Characterization of a₂HSG, a natural inhibitor of human insulin receptor tyrosine kinase
Advisor:  Marilynn Doscher

Michael Malkowski, Ph.D.
Thesis Title: Structural insight into the receptor binding differences exhibited by a-Chemokines and the changes that occur in bovine a-Thrombin upon ligand binding using x-ray crystallographic methods
Advisor:  Brain Edwards

Lisa Polin, Ph.D.
Thesis Title: Characterization of the gene regulatory properties of B- and C- ring analogues of estradiol-17B
Advisor:  Samuel Brooks



Siting Chen, Ph.D.
Thesis Title: Transcriptional regulation of the mammalian CAD gene
Advisor:  David Evans

Carmen Kelly, Ph.D.
Thesis Title: Kinetic studies of three analogs of the RNASE 1-118: 111-124 semisynthetic complex in which aspartic acid-121 has been replaced by asparagine, alanine or cysteic acid
Advisor:  Marilynn Doscher

Randy Schemidt, Ph.D.
Thesis Title: Assembly and function of the ESCHERICHIA COLI F1Fo ATPASE B and c subunits
Advisor:  William Brusilow

Weiping Shi, Ph.D.
Thesis Title: Identification of a metal binding site of the ARSR metalloregulatory protein
Advisor:  Barry Rosen

Xia Wang, Ph.D.
Thesis Title: Fractionation of drosophila RNA polymerase II transcription factors and molecular cloning of RNAP II transcription factor dtfiie
Advisor:  William Zehring



Junli Feng, Ph.D.
Thesis Title: Mechanism of transcriptional regulation of the nitrogen-regulated promoters in the enteric bacteria
Advisor:  Barry Rosen

Mikehl Hafner, Ph.D.
Thesis Title: Examination of the Effect of Estrogen Structure on Transcriptional Activation of Cathepsis D and Reporter Genes in MCF7 Cells
Advisor: Samuel Brooks

Jeanne Ohrnberger (Duffeck), Ph.D.
Thesis Title: Cloning and characterization of a heterokaryon incompatibility suppressor locus
Advisor:  Robert Akins

Thomas Wiese, Ph.D.
Thesis Title: Characterization of ligand specific regulation of the estrogen receptor
Advisor:  Samuel Brooks


Man Chang, Ph.D.
Thesis Title: A study on the unusual complementation for maltose fermentation at the Mal6 of Saccharomyces cerevisiae
Advisor:  Richard Needleman

Michael Davis, Ph.D.
Thesis Title: Examination of the effect of Ligand Structure on Estrogen mediated transcription and estrogen receptor
phosphorylatron in MCF-7 cells
Advisor:  Samuel Brooks

Saibal Dey, Ph.D.
Thesis Title: The relationship of arsenite efflux systems to arsenite resistance in prokaryotes and eukaryotes
Advisor:  Barry Rosen

Xin Liu, Ph.D.
Thesis Title: An arsenic metallochaperone for an arsenic detoxification pump
Advisor:  Barry Rosen

Jose Molina, Ph.D.
Thesis Title: Cloning, expression, and characterization of the ATCASE domain of the multifunctional protein CA
Advisor:  David Evans

MaryJo Pilat, Ph.D.
Thesis Title: Studies on gene induction by estradiol and its analogues in neoplastic and immortalized human breast epithelial
cell lines
Advisor:  Samuel Brooks

Kan-Jen Tsai, Ph.D.
Thesis Title: Biochemical characterization of the cadA cadmium resistance determinant from staphylococcal plasmid pI258
Advisor:  Barry Rosen

Joyce Vanderkuur, Ph.D.
Thesis Title: Influence of estrogen structure on nuclear binding and gene induction by the receptor complex
Advisor:  Samuel Brooks

Mona Wahby, Ph.D.
Thesis Title: Early biochemical events in the captan induction of rat gastrointestinal cell proliferation
Advisor:  Adhip Majumdar



Barna Dey, Ph.D.
Thesis Title: Chaperone function of YDJ1 in P60 v-src-Mediated lethality and cell cycle progression in yeast
Advisor:  Frank Boschelli

Michele Glinn, Ph.D.
Thesis Title: Lipid peroxidation in the mitochondrial inner membrane
Advisor:  C.P. Lee

Robert Monticello, Ph.D.
Thesis Title: Assembly of the Escherichia coli F(1)F(0) proton -translocating ATPase
Advisor:  William Brusilow

Michele Sciamanna (Fabi), Ph.D.
Thesis Title: Ischemia and ischemia/reperfusion induced injury to forebrain mitochondrial energy transducing systems
Advisor:  C.P. Lee



Baofu Ni, Ph.D.
Thesis Title: Regulation of MAL6 gene expression in yeast
Advisor:  Richard Needleman

Jeanne Stuckey, Ph.D.
Thesis Title: The structural refinement of native bovine platelet factor 4 and recombinant human platelet factor 4
Advisor:  Brian Edwards

Ding Wang, Ph.D.
Thesis Title: Purification of band 7.2b, a 31k integral phosphoprotein absent in hereditary stomatocytosis
Advisor:  Robert Johnson



Kiflai Bein, Ph.D.
Thesis Title: Molecular cloning of the CAD cDNA and the regulation of CAD exression
Advisor:  David Evans

Michael Chaparian, Ph.D.
Thesis Title: De Novo pyrimidine biosynthesis : the significance of biological organization in mammalian cells
Advisor:  David Evans

Aziz Qabar, Ph.D.
Thesis Title: Studies on the subunit structure of invertebrate extracellular chlorocruorin from the marine polychaete eudistylia vancouverii : a hierarchy of globin complexes
Advisor:  Serge Vinogradov

Joshua Scully, Ph.D.
Thesis Title: Comparative modeling of the mammalian aspartate transcarbamoylase domain
Advisor: David Evans